Treatment-Resistant Depression

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Severely depressed man sitting outside by the water

What is Treatment-Resistant Depression?

Treatment-resistant depression (TRD) is a type of major depressive disorder (MDD) that does not respond well to traditional forms of treatment, such as antidepressant medications and psychotherapy. People with TRD may experience severe symptoms that can interfere with their ability to function in day-to-day life.

    Signs of Treatment-Resistant Depression

    The signs and symptoms of TRD can vary from person to person and are comparable to the common symptoms of major depressive disorder (MDD). Distinguishing between the two will require a comprehensive evaluation by a mental health professional.

    Common symptoms of TRD include:

    • Persistent sadness or emptiness.
    • Loss of interest in activities.
    • Difficulty concentrating and fatigue.

    Ultimately, you will need the guidance of a specialist to make an accurate diagnosis but if you have been living with depression and not seeing the results you want from treatment, it’s important to consult with your doctor to see if you have Treatment-Resistant Depression.

      woman sits on couch attempting to cope with racing thoughts
      woman sits on couch attempting to cope with racing thoughts

      Signs of Treatment-Resistant Depression

      The signs and symptoms of TRD can vary from person to person and are comparable to the common symptoms of major depressive disorder (MDD). Distinguishing between the two will require a comprehensive evaluation by a mental health professional.

      Common symptoms of TRD include:

      • Persistent sadness or emptiness.
      • Loss of interest in activities.
      • Difficulty concentrating and fatigue.

      Ultimately, you will need the guidance of a specialist to make an accurate diagnosis but if you have been living with depression and not seeing the results you want from treatment, it’s important to consult with your doctor to see if you have Treatment-Resistant Depression.

        Hopeless Young woman talking with her Therapist

        How is TRD treated?

        STEP 1: TMS Therapy

        Meet with an expert for a personalized treatment plan.

        STEP 2: Medication Management

        Start non-invasive TMS sessions

        STEP 3: Esketamine

        
Complete your treatment series and enjoy lasting improvements in your mental health.

        STEP 4: Telemedicine

        
Complete your treatment series and enjoy lasting improvements in your mental health.

        Have more questions about TRD?

        How is TRD diagnosed?

        There is no one specific test or set of criteria used to diagnose TRD. A diagnosis may be made based on a comprehensive assessment that includes a review of your medical history, family history, symptoms, and other factors. Your doctor may also perform a physical exam and order laboratory tests to rule out other conditions that may be causing your symptoms.

        What causes TRD?

        The exact cause of TRD is not fully understood, but it is thought to be caused by a combination of physical, psychological, and social factors. Physical factors that may contribute to TRD include changes in brain chemistry or structure, hormonal imbalances, and health conditions like thyroid disorders or sleep disorders. Psychological factors that may contribute to TRD include negative thinking patterns, trauma, and stress. Social factors that may contribute to TRD include isolation, poverty, and chronic stress.

        Can TRD be cured?
        TRD cannot be cured, but it is a treatable condition. With proper treatment, most people with TRD can manage their symptoms and live relatively normal lives.