Treatment-Resistant Depression

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BestMind patient experiencing depression.

What is Treatment-Resistant Depression?

Treatment-resistant depression (TRD) is a type of major depressive disorder (MDD) that does not respond well to traditional forms of treatment, such as antidepressant medications and psychotherapy. People with TRD may experience severe symptoms that can interfere with their ability to function in day-to-day life.

Signs of Treatment-Resistant Depression

The signs and symptoms of TRD can vary from person to person and are comparable to the common symptoms of major depressive disorder (MDD). Distinguishing between the two will require a comprehensive evaluation by a mental health professional.

Common symptoms of TRD include:

Persistent sadness or emptiness.
Loss of interest in activities.
Difficulty concentrating and fatigue.

Ultimately, you will need the guidance of a specialist to make an accurate diagnosis but if you have been living with depression and not seeing the results you want from treatment, it’s important to consult with your doctor to see if you have Treatment-Resistant Depression.

BestMind patient learning more about treatment resistant depression.

How is TRD treated?

Step 1: Comprehensive Evaluation

Meet with a licensed expert to review your depression history, previous treatments, and current symptoms. This assessment helps determine which advanced TRD treatment may be right for you.

Step 2: Explore Advanced Treatment Options

TMS Therapy: A safe, non-invasive treatment that uses magnetic stimulation to target brain regions linked to depression.
Esketamine (SPRAVATO®): An FDA-approved therapy shown to help individuals with treatment-resistant depression.
Medication Management: Careful review and adjustments to prescriptions that may support your progress.

Step 3: Ongoing Care and Support

Treatment doesn’t end after one option. Through in-person visits or telemedicine sessions, our care team provides consistent follow-up, adjustments, and support to help you achieve long-term relief.

STEP 4: Telemedicine

Complete your treatment series and enjoy lasting improvements in your mental health.

Have more questions about TRD?

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How is treatment-resistant depression (TRD) diagnosed at BestMind Behavioral Health?

Treatment-resistant depression (TRD) diagnosis at BestMind Behavioral Health involves comprehensive psychiatric evaluations including detailed review of previous antidepressant trials, medical history, and current symptoms. Our psychiatrists assess TRD when patients haven’t achieved adequate response to multiple evidence-based depression treatments. We provide thorough TRD evaluations throughout Oregon and Washington, utilizing clinical expertise and standardized assessments.

What causes treatment-resistant depression (TRD)?

Treatment-resistant depression (TRD) occurs when major depressive disorder does not improve after trying at least two different antidepressant therapies. The exact cause is not fully understood, but TRD often results from a mix of factors, including genetics, changes in brain chemistry, chronic physical health issues, long-term stress, trauma, and environmental challenges. Chronic stress and medical conditions like thyroid disorders or sleep problems can make depression harder to treat. TRD affects people throughout Oregon and Washington, and a personalized evaluation at a local BestMind Behavioral Health clinic can help identify underlying factors contributing to persistent depression.

Can treatment-resistant depression (TRD) be cured?

Treatment-resistant depression (TRD) cannot be fully cured, but it is a treatable condition. With personalized care at BestMind Behavioral Health Behavioral Health clinics in Oregon and Washington, many patients achieve significant symptom improvement and lead fulfilling lives. Modern treatments for TRD, such as medication management, transcranial magnetic stimulation (TMS), and Esketamine (SPRAVATO®), can help reduce symptoms and restore quality of life for local patients, even when traditional antidepressants have not worked.

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