Treatment-Resistant Depression

If standard depression treatments aren’t working, you may have treatment-resistant depression. TRD is an often misunderstood condition that can be frustrating and difficult to deal with.

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What is Treatment-Resistant Depression?

Treatment-resistant depression (TRD) is a type of major depressive disorder (MDD) that does not respond well to traditional forms of treatment, such as antidepressant medications and psychotherapy. People with TRD may experience severe symptoms that can interfere with their ability to function in day-to-day life.

Signs of Treatment-Resistant Depression

The signs and symptoms of TRD can vary from person to person and are comparable to the common symptoms of major depressive disorder (MDD). Distinguishing between the two will require a comprehensive evaluation by a mental health professional.

Common symptoms of TRD include:

Persistent sadness or feelings of emptiness
Angry outbursts, irritability, or frustration over small matters
Loss of interest or pleasure in activities you once enjoyed
Sleep disturbances, including insomnia or sleeping too much
Fatigue or decreased energy
Changes in appetite or weight
Anxiety, restlessness, or agitation
Slowed thinking, speaking, or body movements
Feelings of worthlessness or guilt
Difficulty concentrating, making decisions, or remembering things
Frequent thoughts of death or suicide

Ultimately, you will need the guidance of a specialist to make an accurate diagnosis but if you have been living with depression and not seeing the results you want from treatment, it’s important to consult with your doctor to see if you have Treatment-Resistant Depression.

How is TRD treated?

TMS Therapy

TMS Therapy is an FDA-approved procedure that can relieve Treatment-Resistant Depression using electromagnetic waves to stimulate parts of the brain that control mood.

Medication Management

Medication management is an ongoing process between patient and provider that helps find the right medication and dosage to treat your symptoms both safely and effectively.

Esketamine (SPRAVATO®)

Esketamine (SPRAVATO®) is an FDA-approved nasal spray prescribed in conjunction with oral medication to help relieve symptoms of Treatment-Resistant Depression and Major Depressive Disorder.

Telemedicine

Telemedicine appointments take place over our virtual video conferencing platform which allows you to connect with a BestMind provider from anywhere with internet connection.

How is TRD diagnosed?

There is no one specific test or set of criteria used to diagnose TRD. A diagnosis may be made based on a comprehensive assessment that includes a review of your medical history, family history, symptoms, and other factors. Your doctor may also perform a physical exam and order laboratory tests to rule out other conditions that may be causing your symptoms.

What causes TRD?

The exact cause of TRD is not fully understood, but it is thought to be caused by a combination of physical, psychological, and social factors. Physical factors that may contribute to TRD include changes in brain chemistry or structure, hormonal imbalances, and health conditions like thyroid disorders or sleep disorders. Psychological factors that may contribute to TRD include negative thinking patterns, trauma, and stress. Social factors that may contribute to TRD include isolation, poverty, and chronic stress.

How common is TRD?

TRD is a relatively common condition. It is estimated that about one in three people with major depressive disorder (MDD) will not respond to traditional forms of treatment.

Can TRD be cured?

TRD cannot be cured, but it is a treatable condition. With proper treatment, most people with TRD can manage their symptoms and live relatively normal lives.